Systematic Review of Combination Therapies for Facial Aging

Field

Aesthetic Medicine

Study type

Systematic review and evidence synthesis

Challenge

The evidence base contained heterogeneous combination therapies, overlapping study families, different treatment sequences, and safety outcomes that could easily be double-counted or compared inappropriately.

Approach

The review used a predefined eligibility framework, structured treatment-group taxonomy, report-versus-cohort reconciliation, study-family linkage, design-specific risk-of-bias tools, and explicit rules for deciding when pooling was or was not defensible.

Methods

PRISMA 2020 · PRISMA-S · RoB 2 · JBI appraisal · Study-family reconciliation · GRADE planning

Software / workflow

Reference-management workflow · Structured extraction ledger

Project outcome

A review architecture was produced with a reconciled included-report set, transparent treatment grouping, risk-of-bias workflow, safety extraction plan, and publication-oriented main-text/supplement structure.

This case study is intentionally anonymized. Client names, institutions, exact titles, locations, and confidential source materials are not published.