PROSPERO Protocol Support
PROSPERO protocol support for eligible systematic reviews: review question, eligibility, outcomes, search approach, bias assessment, and synthesis plan.
A prospective review protocol reduces avoidable methodological drift and makes planned methods explicit before results are known. Tezyar helps researchers structure protocol content and prepare information needed for PROSPERO where the review is eligible, without claiming registration until the registry accepts the record.
Define the Review Before Screening
The question, eligibility criteria, outcomes, information sources, and synthesis plan should be coherent before study selection progresses too far.
Plan Risk of Bias and Synthesis
Specify assessment tools and anticipated synthesis methods based on the expected study designs and outcomes.
Record Amendments Transparently
If methods change after registration, document what changed, when, and why rather than silently rewriting the plan.
Eligibility and Registry Requirements
Not every review type is eligible for every registry. Current registry criteria should be checked before preparing a submission.
Frequently Asked Questions
Can you guarantee PROSPERO registration?
No. We can support protocol preparation and submission, but acceptance is controlled by the registry.
Should the protocol be written before screening?
Ideally the key methods are prespecified before screening and synthesis decisions can be influenced by the observed evidence.
Related specialized topics
Systematic review search strategy support for concepts, databases, controlled vocabulary, Boolean logic, documentation, and reproducibility.
Risk-of-bias assessment support using study-design-appropriate tools such as RoB 2, ROBINS-I, and JBI instruments.
GRADE support for rating certainty of evidence across outcomes and preparing transparent evidence profiles.
Meta-analysis support in R for effect-size preparation, random- and fixed-effect models, heterogeneity, subgroup analysis, meta-regression, and forest plots.
PRISMA 2020 support for systematic review reporting, flow diagrams, checklists, methods transparency, and manuscript review.
Network meta-analysis support for multi-treatment evidence networks, assumptions, modelling, inconsistency assessment, ranking, and reporting.